El rol de osterix en la diferenciación osteoblástica: potencial en el tratamiento de afecciones osteoarticulares /  The role of osterix in osteoblastic differentiation: Potential in the treatment of osteoarticular affections

Santiago Andrés Audisio; Pablo Guillermo Vaquero; Edgardo Cesar Verna

doi:10.19137/cienvet-201921101

Santiago Andrés Audisio Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias.
Pablo Guillermo Vaquero Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias
Edgardo Cesar Verna Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias

DOI:

https://doi.org/10.19137/cienvet-201921101

Keywords:

Osterix, Preosteoblast, osteoblast, cell differentiation, bone.

Abstract

This paper revises the Osterix protein and its role in the skeletongenesis, the endochondral ossification and in various pathological processes of the osteoarticular systems in animals. Osterix is a transcription factor of the family of bone morphogenic proteins, which prompts
bone formation. In the skeletogenesis Osterix allows the differentiation of the preosteoblasts into osteoblasts and the maturity and differentiation of osteoblasts into osteocytes. In the endochondral ossification, Osterix expresses in the mature and hypermature chondrocytes and contributes to degrade the cartilage matrix. In the extrauterine
life, it collaborates in the regulation of the bone homeostasis and it is involved in osteoarticular pathologies, in bone oncology and in the repair of fractures. Learning about the action of Osterix on the bone cells and chondrocytes is an attractive starting point for further research aiming at contributing to the diagnosis and treatment of diseases of the osteoarticular system in animals.

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Author Biographies

Santiago Andrés Audisio, Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias.

Profesor Adjunto Cátedra Técnica y Patología Quirúrgica. Especialista en Ciencias Clínicas (FAV-UNRC). Doctor en Ciencia, Tecnología e Innovación Agropecuaria (FAV-UNRC). Área de conocimiento de las afecciones de osteoarticulares y cirugía ortopédica y traumatológica veterinaria

Pablo Guillermo Vaquero, Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias

Jefe de Trabajos Prácticos Cátedra Técnica y Patología Quirúrgica. Especialista en Educación en Cs Veterinarias (FCV-UNLPam), doctorando en Ciencias Veterinarias (FCV-UNLP). Área de conocimiento de las afecciones osteoarticulares y cirugía ortopédica y traumatológica veterinaria

Edgardo Cesar Verna, Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias

Cátedra Técnica y Patología Quirúrgica. Especialista en Educación en Cs Veterinarias (FCV-UNLPam). Área de conocimiento afecciones osteoarticulares de los animales domésticos.

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