Gastroprotective effect of Equisetum giganteun (Cola de caballo) and Cortaderia selloana (Cortadera) in rats

Abstract

The gastroprotective effect of two plants of La Pampa province Equisetum giganteun L. and Cortaderiaselloana (Schult&Schult. f.) were utilised in an ulcer incited model by hypothermia and immobilisation in rats. Aerial parts of the plants were dried in a heater by air flow at 60 °C. The vegetable drug was extracted by ethanol:water solvent (1:1, v/v). The Mus musculus rats were allotted in groups of five animals each. The observer group (OG) received an oral dose of 0,5 ml of excipient (Ex) composed by carboxymethylcellulose and tween 80 (1:1, v/v). The control group (CG) received 0,05 mg/kg of atropine subcutaneously and 0,5 ml of Ex orally, by contrast, the treated groups (GTEg and GTCs) received an oral dose of 1 gram hydro-alcoholic extract. The results, of both control and treatments groups, were com­pared and analysed with the results of the observed group by the student t-test. The atropine administered to the CG preven­ted the ulcer formation in all animals group. The two evaluated plants showed significant gastroprotective effect (p≤0,01) in re­lation to the CG. It concluded that the extract of the evaluated plants prevented the ulcer formation induced by stress in rats.